Director - Medical - Cancer Epigenetics - GSK - Collegeville

Job description
The Medical Director is accountable for the clinical development of novel Cancer Epigenetics (CE) assets such as Bromodomain Extra Terminal (BET) and Lysine Specific Demethylase (LSD1) inhibitors that are being developed to treat cancer by altering the epigenetic code of cancer cells. The candidate will be responsible for the development of early oncology asset from first time in human (FTIH) clinical trials through Proof-of-Concept studies.
This is an exciting opportunity to be instrumental in the success of this group and benefit cancer patients. This role requires matrix leadership to drive medical program within cancer epigenetics and establish combination strategies with internal and external assets.
Cancer Epigenetics is one of two strategic research areas of GSK Cancer Research. Cancer Epigenetics ia a fast developing field that takes a novel approach to treat cancer by altering the epigenome of the cancer cell and making them susceptible to growth arrest or death. The program encompasses both solid tumor and hematologic malignancies in multiple ongoing studies and plans to expand quickly.

The Medical Director of Clinical Development will be an Oncology Physician who will eventually lead Project and Clinical Matrix Teams for pre-POC assets thus being accountable for the clinical development of an investigational anti-cancer agent through to POC determination. This will include activities from Candidate Selection through to Proof of Concept and will require accountability for the provision of design for phase 1 and phase 2 clinical studies; development of high quality clinical plans and data analysis strategies that encompass appropriate imaging, biomarkers, surrogate endpoints, and enabling technologies. Strong self-motivation and perseverance are desired.

Vision and strategy: a passion to develop novel therapeutics for cancer patients. Understanding of areas of unmet clinical need and the ability to integrate this with the drug development activities required to advance compounds to POC trials. Understanding of technical aspects relevant to early drug development in the pharmaceutical industry including knowledge of GCP, regulatory processes (US and International) is desirable. Experience working collaboratively with key external oncology experts
Leadership: Ability to implement the clinical vision and strategy. To lead matrix-manage a cross-functional team with integrity, flexibility and forthright communication. Very good interpersonal skills and the ability to meet project objectives by influencing and motivating key partners. Alignment with and commitment to GSK Oncology vision and goals.

Judgment: Evidence of good clinical and scientific judgment. Ability to interpret the significance of preclinical and clinical data, and to anticipate the information that will be needed to satisfy regulatory requirements for early and late phase oncology studies. Ability to progress projects safely and efficiently. Know when to seek advice from colleagues and senior management.
Collaboration and Teamwork: Interact effectively across boundaries with other functions and disciplines using influencing, communication and relationship building skills. Able to secure, manage and maintain critical partnerships with key business partners.

*LI-GSK • M.D. degree with sub-specialty in Oncology and clinical development experience is required
• 5+ years of relevant medical/clinical or pharmaceutical experience
• Keen understanding of drug development
• Proven ability to strategize, prioritize, and manage multiple projects simultaneously to ensure quality, timely, on-target and within budget accomplishment of tasks.
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• Ability to embed medical functional skills and strategic thinking into teams
• Attention to detail with excellent planning, time management and organizational skills
• Excellent communication and presentation skills, high- level negotiation skills and the ability to resolve conflict in a constructive manner

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