Thursday, March 30, 2017

Pharmacometrician Director Pfizer New York

Job Description: • 2-minute read •
In this key role as a member of our Global Pharmacometrics group within the Clinical Pharmacology Department, you will be responsible for providing expert study/program design, data analytical and interpretation inputs to our various Research, Development and Business Unit organizations. The successful candidates will work as partners of disease area aligned multi-disciplinary teams in providing model informed drug discovery and development expertise and leadership to a variety of through to loss of patent exclusivity. Of key importance will be the formation and maintenance of effective collaborations with amongst others, statistical, clinical and clinical pharmacology members of these teams.
Pharmacometricians provide strategic input into pre-clinical discovery, development and post-approval plans quantifying the risk associated with particular study designs or program strategies and communicating/dissemination of the results. They are responsible for the use of a variety of innovative quantitative methods to integrate knowledge of pharmacokinetics, a variety of response variables (including pharmacodynamic, clinical outcome and undesirable effects), patient characteristics and disease mechanism/states, statistics, study/experimental design, clinical trial simulations, meta-analytical evidence synthesis and quantitative techniques to facilitate quantitative decision making thereby increasing drug research and development efficiency.

In addition to the disease specific project activities the successful candidates will forge collaborative relationships with Pharmacometric colleagues within the Global Pharmacometrics community (currently based in USA, UK, China and Japan), other subject matter specialists and groups external to the organization (leading academics, external service providers etc.). The successful candidates will work with colleagues to ensure Pfizer's position as a leader in the use of quantitative approaches supporting drug research and development strategies and worldwide registration of new medicines.

Pharmacometricians routinely interact with internal governance bodies, regulatory agencies and external opinions leaders. They are expected to influence the external environment by advancing their discipline and through external presentations and publications.


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Responsibilities
• Hands-on modelling and simulation.

• Support model informed drug discovery and development (MID3) strategies.

• Interaction with clinical pharmacology and other project team colleagues including clinicians and statisticians.

• Collaboration with the global Pharmacometric community.

Qualifications
The ideal candidates will have a doctorate degree with demonstrated expertise in Pharmacometrics and strong quantitative skills (e.g. experience in mechanistic modelling/systems pharmacology, quantitative translational scaling, literature meta-analyses, population PK and PK-PD modelling, and clinical trial simulations). We encourage applicants from different disciplines including pharmaceutical sciences, biostatistics, medicine, engineering, etc. Candidates with significant experience are sought as well as recent graduates. In addition to professional challenge, we offer a culture that supports and encourages ideas, and recognizes individual contribution. Moreover, the salary and extensive benefits are everything you'd expect from a world leading company

Other Information - Internal
Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.
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